Start triage by removing the accounts that are supposed to be here. SubjectUserName values of SYSTEM, NETWORK SERVICE, and LOCAL SERVICE, plus any account name ending in a dollar sign (computer accounts and, on some estates, service accounts provisioned with machine-style naming), account for the overwhelming majority of 4672 volume on any server or domain controller. Filtering these out first is not optional; without it, every hunt drowns before it starts.
On a domain controller, machine-account 4672 entries tied to replication, LDAP binds, and Group Policy refresh are expected background noise, as is a genuine Domain Admin logging on interactively during business hours from their known jump box. Confirm the last part by joining SubjectLogonId to the matching 4624 and checking LogonType (2 for interactive, 10 for RemoteInteractive/RDP) and the source workstation or IP against what that admin normally uses. A privileged logon that checks out on all three, expected account, expected source, expected hour, is a true positive for "privilege granted," but a false positive for "something is wrong."
The pattern worth escalating is the mismatch. A standard user account or a low-privilege service account receiving SeDebugPrivilege or SeImpersonatePrivilege for the first time in its history is the single strongest signal 4672 offers, particularly on a workstation rather than a server, since workstations rarely need any of these thirteen rights outside of local Administrator sessions.
Pair that with the LogonId trail: if the 4624 behind the 4672 shows an unfamiliar source IP, an off-hours timestamp, or a logon type that does not match how that account is supposed to authenticate (a service account showing LogonType 10, for example), the privilege grant is riding on top of a suspicious authentication event, not a benign one.
Use 4673 as the tiebreaker when the account itself looks ambiguous. A 4672 with no corresponding 4673 for hours or days means the privilege was granted but never exercised, which lowers urgency without eliminating it as a finding worth a baseline update. A 4673 that follows within seconds and names a sensitive target, lsass.exe under SeDebugPrivilege, the SAM or NTDS.dit path under SeBackupPrivilege, is close to unambiguous evidence the privilege is being actively used for something an analyst should look at immediately.
Finally, baseline the volume itself per host. A domain controller or admin jump box that produces hundreds of 4672 events an hour is normal for that host; the same count on a line-of-business workstation that historically logs two or three a month is not, regardless of which account or privilege is involved. Building that per-host baseline, and alerting on deviations from it, catches automated enumeration, repeated persistence-mechanism restarts, and compromised-service reuse that individual-event filtering on account name or privilege name alone will miss.